Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors
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Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors
Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors Undurti N. Das Phosphodiesterase-5 enzyme inhibitors (PDE-5-Is) such as sildenafil, vardenafil and tadalafil are used in the treatment of male erectile dys-function (ED). Their beneficial action can be attributed to an increase in the intracellular cGMP level due to inhibition of PDE-5 and conse...
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15 صفحه اولRepurposing phosphodiesterase-5 inhibitors as chemoadjuvants
Phosphodiesterase-5 (PDE5) inhibitors have shown a beneficial effect in a variety of clinical conditions, such as benign prostate hyperplasia, pulmonary arterial hypertension, female sexual arousal disorder, overactive bladder, and incontinence, Raynaud’s disease, heart failure and stroke among others (Sandner et al., 2007). Three PDE5 inhibitors, sildenafil (ViagraTM), tadalafil (CialisTM) and...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2017
ISSN: 1734-1922
DOI: 10.5114/aoms.2017.64723